IGF-I and mammographic density in four geographic locations: A pooled analysis
نویسندگان
چکیده
منابع مشابه
Plasma insulin-like growth factor (IGF) I, IGF-binding protein 3, and mammographic density.
Insulin-like growth factors (IGFs) and insulin-like growth factor-binding proteins (IGFBPs) play a role in the normal development of breast tissue and possibly in the etiology of breast cancer. Breast density is one of the strongest predictors of breast cancer. In a cross-sectional analysis within the Nurses' Health Study, we compared the associations of plasma levels of endogenous IGF-I and IG...
متن کاملLongitudinal changes in IGF-I and IGFBP-3, and mammographic density among postmenopausal women.
A relation between the breast cancer risk factors, insulin-like growth factor-I (IGF-I) and mammographic density, is biologically plausible, but results from cross-sectional epidemiologic studies have been mixed. Our objective was to examine the relation in a longitudinal manner, that is, between the change in circulating IGF-I concentrations and the change in mammographic measures over one yea...
متن کاملShort Communication Longitudinal Changes in IGF-I and IGFBP-3, and Mammographic Density among Postmenopausal Women
A relation between the breast cancer risk factors, insulin-like growth factor-I (IGF-I) and mammographic density, is biologically plausible, but results from cross-sectional epidemiologic studies have beenmixed. Our objective was to examine the relation in a longitudinal manner, that is, between the change in circulating IGF-I concentrations and the change in mammographic measures over one year...
متن کاملMammographic density and ageing: A collaborative pooled analysis of cross-sectional data from 22 countries worldwide
BACKGROUND Mammographic density (MD) is one of the strongest breast cancer risk factors. Its age-related characteristics have been studied in women in western countries, but whether these associations apply to women worldwide is not known. METHODS AND FINDINGS We examined cross-sectional differences in MD by age and menopausal status in over 11,000 breast-cancer-free women aged 35-85 years, f...
متن کاملInsulin-like growth factor-I, IGF-binding protein-3, and mammographic breast density.
Some studies have suggested that insulin-like growth factor (IGF) pathway is related to premenopausal breast density, one of the strongest known breast cancer risk factors. This study was designed specifically to test the hypothesis that higher levels of IGF-I and lower levels of IGF-binding protein (IGFBP)-3 are associated with high mammographic breast density among premenopausal but not among...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2007
ISSN: 0020-7136,1097-0215
DOI: 10.1002/ijc.22834